Abstract
A single administration of an iodine thyroid blocking agent is usually sufficient to protect thyroid from radioactive iodine and prevent thyroid cancer. Repeated administration of stable iodine (rKI) may be necessary during prolonged or repeated exposure to radioactive iodine. We previously showed that rKI for eight days offers protection without toxic effects in adult rats. However, the effect of rKI administration in the developing foetus is unknown, especially on brain development, although a correlation between impaired maternal thyroid status and a decrease in intelligence quotient of the progeny has been observed. This study revealed distinct gene expression profiles between the progeny of rats receiving either rKI or saline during pregnancy. To understand the implication of these differentially expressed (DE) genes, a systems biology approach was used to construct networks for each organ using three different techniques: Bayesian statistics, sPLS-DA and manual construction of a Process Descriptive (PD) network. The PD network showed DE genes from both organs participating in the same cellular processes that affect mitophagy and neuronal outgrowth. This work may help to evaluate the doctrine for using rKI in case of repetitive or prolonged exposure to radioactive particles upon nuclear accidents.
Highlights
A single administration of an iodine thyroid blocking agent is usually sufficient to protect thyroid from radioactive iodine and prevent thyroid cancer
A systems biology approach was used to identify a putative molecular mechanism that could explain the effect of the iodine thyroid blocking agent KI on the thyroid and brain cortex
The Process Descriptive (PD) diagram represents molecular mechanisms[14] and identifies genes belonging to key events that may be associated with the adverse outcome (AO)
Summary
A single administration of an iodine thyroid blocking agent is usually sufficient to protect thyroid from radioactive iodine and prevent thyroid cancer. The recent 2011 Fukushima Daiichi disaster suggested that the World Health Organization’s “ITB guidelines”[2] that so far supported a single intake of 130 mg potassium iodide (KI) tablet for individuals older than 12 years, cannot adequately protect populations in case of prolonged (beyond 24 h) or repeated exposure In such situations, a second intake of stable iodine is possible, the “ITB guidelines” so far give no indication on how to implement such repeated administration of KI2,3. Repeated ITB administration for eight consecutive days in gestational rats, as a model for pregnant women, led to AO effects, such as changes in expression of thyroid hormone-responsive genes in the brain and motor coordination, in the offspring[8,13]. Identification of causal relationships between genes from the thyroid and the cortex was explored
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