Effects of removal of the acetabular labrum in a sheep hip model

Abstract

Objective: The aim of this study was to learn whether partial resection of the acetabular labrum would lead to degenerative arthritis in an ovine model. Methods: A 2 cm segment of labrum was removed from one hip in 18 mature Swiss Alpine sheep and a sham procedure was performed on the opposite side. Animals were permitted ad lib activity until sacrifice at 6, 12 or 24 weeks. The hip joint was removed en bloc, and loaded with a force of one body weight, using a custom device designed to recreate a physiologic joint reaction force. While under load, the joint was plunge frozen, and then fixed by freeze substitution using aldehydes in methanol/acetone solvents. The entire joint was embedded in methacrylate and sectioned in a standardized frontal plane following the reaction force and including the femoral neck and the acetabular fossa. The sections were evaluated for concentricity and evidence of arthrosis. Six hip joints of three sheep with no surgical procedure were loaded with high or low loads and served as non-surgical controls. Results: Degenerative changes were present in all surgical hips, but the changes were symmetrical and mild. In 16 of 18 hips, the labrum regenerated to the extent that dense fibrous scar extending from the surgically denuded origin filled the defect. Conclusion: Resection of the labrum does not cause rapid degeneration or altered stability of the sheep hip.