Abstract
Objective To explore the effects of rectal administration of diclofenac sodium suppository on postoperative pain, inflammatory response, and postoperative recovery in elderly patients undergoing colorectal surgery. Methods A total of 60 65-80 years old patients taking colorectal surgery at our hospital from June, 2016 to February, 2018 were randomly divided into a test group and a control group, 30 cases for each group. The test group rectally administrated diclofenac sodium suppository and took postoperative patient-controlled intravenous analgesia (PCIA) ; and the control group took PCIA. The outcomes of postoperative analgesia were recorded before (T0) and 2 h (T1) , 6 h (T2) , 12 h (T3) , 24 h (T4) , and 48 h (T5) after the operation. The levels of plasma interleukin 6 and 8 (IL-6 and IL-8) , tumor necrosis factor-alpha (TNF-α) , and C-reactive protein (CRP) at T0 to T5 were detected in the two groups. The postoperative recovery was observed in the two groups. Results At T1 to T4, the scores of VAS were lower in test group than in the control group (all P<0.05) . The times of PCA 24 h after the operation were lower and the satisfaction were higher in the test group than in the control group, with statistical differences (P<0.05) . The serum levels of IL-6 at T2-5 were lower, the serum levels of IL-8 at T1-5 were lower, and the serum levels of plasma TNF-αat T2-4 were lower in the test group than in the control group (all P<0.05) . The recovery of intestinal function after the operation and postoperative recovery were better in the test group than in the control group (P<0.05) . Conclusion Preemptive analgesia of rectal administration of diclofenac sodium suppository combined with PCIA for elderly patients with radical colon cancer can relieve their postoperative pain and reduce inflammation, and is helpful for their rapid recovery after surgery. Key words: Non-steroidal analgesics; Multimodal analgesia; Inflammation; Colorectal surgery; Elderly
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
