Abstract
The effects of reaction variables (temperature, pressure, solvent type, substrate to catalyst ratio and substrate concentration) on enantioselectivity of methyl acetoacetate hydrogenation were studied. Raney nickel modified with ( 2R,3R)-(+)-tartaric acid was used as a catalyst. The reactions were carried out in a liquid phase, under atmospheric and increased hydrogen pressure. It was found that the reaction variables have a significant effect on the resulting enantioselectivity. A decrease of enantioselectivity either occurred at low substrate concentration in the reaction mixture or related to a catalyst. Changes of enantioselectivity were monitored during the reaction. The highest values of enantioselectivity were achieved under high hydrogen pressures (10 MPa), at a temperature of 60 °C and with tetrahydrofuran as the solvent.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
