Abstract

目的 探讨奎硫平与利培酮治疗痴呆患者行为与精神障碍的疗效及安全性.方法 以中国精神疾病分类与诊断标准(CCMD-3)符合阿尔茨海默病及血管性痴呆患者56例分为两组,奎硫平组27例,给予奎硫平0.05~0.3 g/d;利培酮组29例,给予利培酮1~2 mg/d.观察8周,评定疗效.结果 奎硫平总有效率66.67%,利培酮总有效率65.5%,与治疗前比较两组差异均有统计学意义,药物不良反应基本相当,但奎硫平锥体外系反应极少.结论 奎硫平能很好控制痴呆患者的行为与精神障碍,不良反应轻,值得临床推广。

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