Abstract
To investigate spinal mechanisms of control of locomotion by the pyramidal system, we made intracellular recording from forelimb flexor motoneurons, and analyzed excitatory postsynaptic potentials (EPSPs) evoked by stimulation of the medullary pyramid during forelimb fictive locomotion in immobilized, decerebrate cats. We observed that (1) pyramidal stimulation evoked disynaptic EPSPs, (2) which were much bigger in the locomotor state than in the resting state, and that (3) the pyramidal EPSPs were rhythmically modulated, so that the facilitation occurred in the flexor-active phase. Last-order neurons mediating pyramidal effects presumably receive rhythmic input from the spinal locomotor network.
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