Abstract
Methods Participants using either DMPA (n=15) or the LNG iUS (n=19) for at least 3 months and women using no hormonal contraceptives (n=24) were recruited. Endocervical curettage, endocervical cytobrush, and endometrial biopsy were obtained from all women. Expression of T cell activation markers, memory/effector differentiation markers and HIV co receptors were assessed by multiparameter flow cytometry. CD4+ and CD8+ T cells producing CD107a, IL-10, IL-2, IFNg, MIP1b and IL-17 were measured after stimulation with PMA/ionomycin or staphylococcal enterotoxin B (SEB).
Highlights
Use of progestin-only contraceptives may enhance the susceptibility of the female reproductive tract (FRT) to HIV infection
Background Use of progestin-only contraceptives may enhance the susceptibility of the female reproductive tract
We assessed the effects of progestin-only contraceptives
Summary
Uma Shanmugasundaram1*, JW Critchfield[1], J Pannell[2], J Perry[2], WC Greene[2,3], L Giudice[2], K Smith-McCune[2], RM Greenblatt[2], BL Shacklett[1]. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. From 2nd International Science Symposium on HIV and Infectious Diseases (HIV SCIENCE 2014) Chennai, India. 30 January - 1 February 2014
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
