Abstract
Some preparations of heparin and heparitin sulfate were found to be contaminated with protease inhibitors. By column chromatography two different inhibitors, both of an acid type, could be demonstrated. Inhibitor-free heparin preparations exerted an enhancing effect on fibrinolysis caused by plasminogen activators. Inhibitor-free heparitin sulfate had no enhancing effect. It is believed that these findings explain the discrepant earlier reports on the effects of heparin on fibrinolysis.
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