Abstract

Objective To observe the effects of post-stroke depression (PSD) on cytokines in patients with cerebral ischemic stroke (CIS). Methods Sixty-three patients with CIS admitted to the First Affiliated Hospital of Xinxiang Medical University from March 2016 to October 2017 were divided into PSD group (28 cases) and non-PSD group (35 cases) according to whether the patients had PSD within 6 months after stroke. General data of the patients in the two groups were compared, and the levels of high-sensitivity C-reactive protein (hs-CRP), interleukin-1 (IL-1), interleukin-23 (IL-23), homocysteine (Hcy) and transforming growth factor-β (TGF-β) in the two groups were detected at admission and 6 months after stroke. Results The proportion of female patients in PSD group (60.71%) was higher than that in non-PSD group (14.29%), and the difference was statistically significant (P 0.05). Conclusions Women with CIS are at high risk of PSD. The PSD will activate the immune-inflammatory system and lead to the increase in hs-CRP, IL-1 and TGF-β. Key words: Cerebral ischemic stroke; Post-stroke depression; Inflammatory factors; Transforming growth factor; Homocysteine

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