Abstract
The effects of five polybrominated diphenol ethers from a Marine Sponge, Phyllospongia dendyi, on the relative plating efficiencies in V79 cells and the cell proliferation and IL-8 production in PMA-stimulated HL-60 cells were examined. Three compounds, possessing two phenol units, were reported to inhibit the assembly of microtubule proteins and showed the inhibition of colony formation of V79 cells and increase in IL-8 production. Interestingly, a monomethoxy compound exhibited the stronger activity than the three active compounds in both bioassays. This compound did not inhibit the assembly of microtubule proteins. A dimethoxy compound was not active in either bioassays. In these experimental conditions, the biological activities were not high, but in future, these compounds will be expected to be made stronger by structural modifications.
Highlights
Marine sponges are prolific sources of biologically active agents [1,2]
We attempted to show the effects of these compounds on colony formation in Chinese hamster V79 cells, because the inhibition of microtubules correlates to cell proliferation
The effects of polybrominated diphenol ethers 1–5 on relative plating efficiencies of Chinese hamster V79 cells
Summary
Marine sponges are prolific sources of biologically active agents [1,2]. In the course of our studies on biologically active natural products from marine organisms, we isolated eleven polybrominated diphenol ethers from the ethanol extract of a marine sponge, Phyllospongia dendyi, and reported the structures and the inhibitory activity on the assembly of microtubules in the purified porcine brain microtubule proteins of these compounds [3]. We attempted to show the effects of these compounds on colony formation in Chinese hamster V79 cells, because the inhibition of microtubules correlates to cell proliferation. Compounds 1–3 and 5 showed weak inhibitory activity on colony formation in V79 cells.
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