Abstract
This study was conducted for evaluation of the ability to maintain efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid (HA) filler. Saline and HA solution was administered in the negative and positive control groups, and DiHM and PDiHM were administered in the test groups (n = 10 in each group). The site of cranial subcutaneous injection was the mid-point of the interpupillary line, and the site of intraoral submucosal injection was the ridge crest 2 mm below the cervical line of the mandibular left incisor. Before and immediately after filler injection, intraoral photos and lateral cephalometric radiographs were taken for analysis and comparison of the effect of the filler on the injection sites. The filler injected areas were converted into sequential size changes (%) of the baseline. Histomorphologic examination was performed after 12 weeks. The smallest value in the filler injected area was observed during the experimental period in the normal saline group (p < 0.001), which was almost absorbed at 4 weeks (7.19% ± 12.72%). The HA group exhibited a steady decrease in sequential size and showed a lower value than the DiHM and PDiHM groups (saline < HA < DHiM, PDHiM, p < 0.001). DiHM and PDiHM tended to increase for the first 4 weeks and later decreased until 12 weeks. In this study on DiHM and PDiHM, there was no histological abnormality in cranial skin and oral mucosa. DiHM and PDiHM filler materials with injection system provide an excellent alternative surgical method for use in oral and craniofacial fields.
Highlights
Soft tissue augmentation is required for the functional and esthetic recovery of damaged, absorbed, or deformed tissue
The aim of this study is to perform research on maintaining efficacy and biocompatibility of cross-linked dextran in hydroxypropyl methylcellulose (DiHM) and cross-linked dextran mixed with PMMA in hydroxypropyl methylcellulose (PDiHM), compared with hyaluronic acid filler through oral submucosa and cranial subcutaneous injection in experimental rats
A similar absorption pattern was observed with cranial subcutaneous injection (Saline < Hyaluronic acid (HA) < DiHM, PDiHM, p < 0.001)
Summary
Soft tissue augmentation is required for the functional and esthetic recovery of damaged, absorbed, or deformed tissue. Limited soft tissue volume of donor site, patient’s resistance, discomfort, possibility of graft failure, and lack of angiogenesis due to various amounts of fat tissue included could cause problems [10]. To solve these problems, in some cases use of an injection method using commercially available filler material has been reported [11,12,13]. The experimental part of this study included the oral submucosa area
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