Abstract
Concentrated perfluorocarbon emulsions are known to increase oxygen availability in various tissues, especially during oxygen breathing (for review, see Faithfull, 1992). With respect to the central nervous system, F-decalin and F-tributylamine have been shown to increase oxygen availability in rabbit brain cortex by more than 100 % when oxygen breathing is applied (Clark et al, 1989). In cat retina the increase in tissue partial pressure of oxygen (PO2) during oxygen breathing is significantly enhanced after intravenous injection of perflubron emulsion (Braun et al, 1992). In both of the preceding studies PO2 was measured polarographically in either tranquillized or anaesthetized animals at a certain location in the observed organ. The present study was conducted in order to evaluate the effects of intravenously administered perflubron emulsion on local tissue PO2 at different adjacent locations of the brain cortex in unanaesthetized rabbits, steering clear of possible anaesthesia-induced alterations in cerebral metabolism and perfusion, cerebrovascular reactivity and electrode properties. The effects were studied during air breathing and 100 % oxygen breathing.
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