Abstract
BackgroundAnxiety symptoms are frequently observed in dental patients, whether they are undergoing simple or more invasive procedures such as surgery. This research aimed to compare the effects of Passiflora incarnata and midazolam for the control of anxiety in patients undergoing mandibular third molar extraction.Material and MethodsForty volunteers underwent bilateral extraction of their mandibular third molars in a randomized, controlled, double-blind, crossover clinical trial. Passiflora incarnata (260 mg) or midazolam (15 mg) were orally administered 30 minutes before surgery. The anxiety level of participants was evaluated by questionnaires and measurement of physical parameters, including heart rate (HR), blood pressure (BP), and oxygen saturation (SpO2).ResultsConsidering each procedure independently, there were no significant differences between the protocols in BP, HR, and SpO2. Over 70% of the volunteers responded that they felt quiet or a little anxious under both protocols. With midazolam, 20% of the participants reported amnesia (not remembering anything at all), while Passiflora showed little or no ability to interfere with memory formation.ConclusionsPassiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars. Key words:Passiflora incarnata, midazolam, anxiety, oral surgery.
Highlights
Anxiety can be identified in most patients seeking dental care by observing behavior and recognizing physiological signs of anxiety, such as pupil dilation, pallor, excessive sweating, increased blood pressure and heart rate, tremors, dizziness, dry mouth, weakness, and difficulty breathing
Passiflora incarnata is traditionally used as a mild sedative and anxiolytic worldwide, there is a paucity of evidence from randomized clinical trials to demonstrate this activity
This research aimed to compare the effect of Passiflora incarnata with midazolam in the control of anxiety in patients undergoing extraction of mandibular third molars
Summary
Anxiety can be identified in most patients seeking dental care by observing behavior and recognizing physiological signs of anxiety, such as pupil dilation, pallor, excessive sweating, increased blood pressure and heart rate, tremors, dizziness, dry mouth, weakness, and difficulty breathing. Oral benzodiazepines have a large margin of clinical safety and are easy to administer Despite their low toxicity, patients may experience adverse reactions such as a rash, nausea, or headache. Only 2 published randomized clinical trials [11,12] have reported the anxiolytic effects of preoperative Passiflora incarnata. This research aimed to compare the effects of Passiflora incarnata and midazolam for the control of anxiety in patients undergoing mandibular third molar extraction. Conclusions: Passiflora incarnata showed an anxiolytic effect similar to midazolam, and was safe and effective for conscious sedation in adult patients who underwent extraction of their mandibular third molars
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