Abstract
We tested the hypothesis that oleic-acid (OA) infusion impairs gas exchange, decreases total cardiopulmonary O2 delivery and lowers maximal aerobic capacity (V˙O2max). We infused 0.05ml OAkg−1 (∼3ml) and ∼563ml saline into the right atria of four goats [59.1±14.0 (SD) kg] prior to running them on a treadmill at V˙O2max 2-h and 1-d following OA-induced acute lung injury, and with no lung injury. Acute lung injury decreased V˙O2max, O2 delivery, arterial O2 concentration and arterial O2 partial pressure compared to no lung injury. The V˙O2max positively correlated with O2 delivery and inversely correlated with alveolar–arterial O2 partial pressure difference, suggesting that impaired pulmonary gas exchange decreased O2 delivery and uptake. Results indicate OA infusion may be a useful model for acutely impairing pulmonary gas exchange for exercise studies. Seven OA infusions induced smaller chronic gas exchange and arterial O2 partial pressure changes than acute infusion.
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