Abstract

Objective To investigate the effects of nimodipine combined with mannitol on serum interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and renal function in elderly patients with hypertensive intracerebral hemorrhage (HICH). Methods Ninety-four elderly patients with HICH were divided into single group and combined group according to the treatment regimen and 47 patients in each group. The single group was treated with mannitol and the combined group was treated with mannitol + nimodipine. The effects of the two groups were observed, and the recovery of neurological function (NIHSS), changes of serum IL-1β, TNF-α levels and renal function [blood creatinine (Cr), urea nitrogen (BUN)]before and after treatment were compared. Results The total effective rate in the combined group[95.74% (45/47)]was significantly better than that in the single group (78.72%, 37/47) (P 0.05). Conclusions Nimodipine combined with mannitol in treatment of HICH can significantly improve the therapeutic effect, reduce the levels of serum TNF-α and IL-1β, and promote the recovery of neurological function, and it will not aggravate renal injury. Key words: Nimodipine; Mannitol; Hypertensive intracerebral hemorrhage; Interleukin-1β; Tumor necrosis factor-α; Renal function

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