Abstract
The present communication deals with the possible effect of glucagon released from the alpha-cells upon insulin secretion induced by glucose in the adjacent beta-cells. First, it has been shown that neutral red, a substance which is thought to cause glucagon release from the alpha-cells, did not modify the rate of insulin secretion induced by glucose in pieces of rat pancreatic tissue. Secondly, glucose stimulated insulin secretion under conditions where imidazole, a substance known to activate the phosphodiesterase, completely abolished the stimulant effect of exogenous glucagon upon insulin secretion. It is concluded that glucagon is not necessarily involved in the stimulation of insulin secretion by glucose, and that the effect of locally released glucagon, if any, is only to enhance the stimulant action of glucose.
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