Abstract
Over 20 neurotropic drugs were tested for their ability to interact with microsomal membrane and for their influence on membrane-deoxyribonucleic acid (DNA) associations in vitro. About 85% of the compounds tested altered the density of the membrane in caesium chloride equilibrium density gradients, the macroscopic appearance of the membrane band, and the extent of DNA binding. In three out of five cases studied in greater detail, the decrease in membrane density was correlated with a reduced protein content of the membrane. Theoretical significance and potential practical applications of these observations are considered.
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