Abstract
AbstractThe behavior of the pigeon maintained under a variable‐interval schedule of food presentation was used to compare the activity of four novel N‐substituted acetylmethadol and methadol analogs with that of methadone and (‐)‐α‐acetylmethadol (LAAM). All of the acetylmethadol and methadol analogs had narcotic agonist activity, as defined by the reversibility of their behavioral effects by naloxone. The effect of the N‐substituted analogs on variable‐interval responding was similar to that of methadone and LAAM, but all these compounds had a slower onset of action than methadone and a shorter duration of action than LAAM. None of the N‐substituted analogs showed narcotic antagonist activity when tested against methadone.
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