Effects of Mild Traumatic Brain Injury on Stereopsis Detected by a Virtual Reality System: Attempt to Develop a Screening Test

Abstract

PurposeThe study aimed to evaluate stereopsis as a surrogate marker for post-concussion oculomotor function to develop an objective test that can reliably and quickly detect mild traumatic brain injuries (TBI).MethodsThe cohort of this prospective clinical study included 30 healthy subjects (mean age 25 ± 2 years) and 30 TBI patients (43 ± 22 years) comprising 11 patients with moderate TBI and 19 patients with mild TBI. The healthy subjects were examined once, whereas the TBI patients were examined immediately after hospitalization, at 1 week, and at 2 months. A virtual reality (VR) program displayed three-dimensional rendering of four rotating soccer balls over VR glasses in different gaze directions. The subjects were instructed to select the ball that appeared to be raised from the screen as quickly as possible via remote control. The response times and fusion abilities in different gaze directions were recorded.ResultsThe correlation between stereopsis and TBI severity was significant. The response times of the moderate and mild TBI groups were significantly longer than those of the healthy reference group. The response times of the moderate TBI group were significantly longer than those of the mild TBI group. The response times at follow-up examinations were significantly shorter than those immediately after hospitalization. Fusion ability was primarily defective in the gaze direction to the right (90°) and left (270° and 315°).ConclusionsTBI patients showed impaired stereopsis. Measuring stereopsis in different positions of the visual field using VR can be effective for rapid concussion assessment.