Abstract
The intracellular level of adenosine 3′, 5′-cyclic monophosphate (cyclic AMP) increased in rat glioma (C-6) and mouse neuroblastoma cells (NBP 2) after treatment with methylmercuric chloride (CH 3HgCl). The effects of CH 3HgCl in the presence of cyclic AMP-stimulating agents on glioma cells were in part different from those on NB cells. CH 3HgCl increased prostaglandin E 1 (PGE 1)-induced growth inhibition (due to reduction in cell division and cell death) in glioma and NB cells. CH 3HgCl did not reduce PGE 1-induced formation of cytoplasmic processes in glioma cells except at a higher PGE 1 concentration, but it did decrease PGE 1-induced neurite formation in NB cells. The inhibitors of cyclic nucleotide phosphodiesterase completely prevented the cytotoxic effect of CH 3HgCl on glioma cells, but they markedly enhanced the growth inhibitory effect of CH 3HgCl on NB cells.
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