Abstract
The autoperfused intestinal circulation of pentobarbitone anaesthetized cats was used to study the effects of α,β-methylene ATP (1–100 μg i.a.) on pre-capillary resistance vessels and post-capillary capacitance (venous) blood vessels in comparison with other vasoconstrictor agents (also given i.a.) and the effects of sympathetic nerve stimulation (0.25–16 Hz). AH cats were treated with atropine and propranolol. α,β-Methylene ATP, noradrenaline and sympathetic nerve stimulation all caused dose- or frequency-dependent constriction of both resistance and capacitance vessels. α,β-Methylene ATP was particularly active on capacitance vessels causing a greater constriction than either noradrenaline or sympathetic nerve stimulation. In comparison, angiotensin II and vasopressin caused a selective constriction of resistance vessels and prostaglandin F 2α a selective constriction of capacitance vessels. The results demonstrate that functional P 2x purinoceptors are present on both arterial and venous blood vessels of the cat intestinal circulation.
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