Abstract
An attempt to evaluate experimentally the effects of intrauterine fetal exchange transfusion on placental function is reported. In a series of acute experiments carried out on pregnant sheep and their fetal lambs, maternal-fetal cross transfusion, sufficient significantly to increase the content of maternal blood in the fetus, was successfully carried out. No significant changes in fetal oxygen consumption or umbilical vein blood flow rates were noted. Significant fetal acidosis and an increase in fetal blood PO2, with the ewe breathing either air or oxygen, were seen. The implications are discussed.
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