Year-end Sale % OFF 
Abstract
The hypothesis that gonadotropins and/or gonadal steroids inhibit metamorphosis of neotenic salamanders was investigated in the tiger salamander, Ambystoma tigrinum. Sexually immature larvae were pretreated for 2 weeks with gonadotropins (LH and/or FSH, HCG) or gonadal steroids (testosterone and/or estradiol-17β) followed by continued treatment plus TSH. None of the hormones tested inhibited TSH-induced metamorphosis. LH, in fact, promoted metamorphosis during the pretreatment period, and testosterone accelerated TSH-induced metamorphosis. The induction of metamorphosis by LH can be accounted for in terms of TSH contamination. FSH did not contain sufficient TSH contamination to induce metamorphosis at the dosage employed. The importance of sensitivity of amphibian thyroid glands to mammalian TSH and the implications of TSH contaimination of pituitary gonadotropin preparations are discussed.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
