Abstract
Summary:The effect of long‐term dietary modification on pancreatic exocrine function in rats has been investigated by examining responses to cholecystokinin‐pan‐creozymin stimulation, using a method of direct pan‐creatic duct cannulation. Residual pancreatic enzyme activity remaining in the whole pancreas following stimulation was also measured. After 6 months of dietary modification, changes in the pancreatic secretions of high‐protein‐or high‐fat‐fed animals were similar to those reported in short‐term studies in which elevation of trypsin and lipase activity occurred in the pancreas. However, between 6 and 9 months, both volume and amylase activity of pancreatic secretions decreased in animals fed a high‐protein diet. At 6 and 9 months, animals fed a high‐carbohydrate diet had increased amounts of amylase and decreased trypsin in both pancreatic secretion and homogenate, similar to short‐term changes previously reported. High‐carbohydrate‐fed animals had decreased lipase activity in pancreatic secretions, but lipase activity in pancreatic homogenates was increased, similar to levels found in animals fed a high‐fat diet.
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