Abstract
Mitochondrial dysfunction and consequent cellular energetic failure play a key role in the development of sepsis-related organs failure. Levosimendan, by a calcium-sensitizing mechanism increases myocardial contractility while simultaneously exerting vasodilatory properties via activation of ATP-dependent potassium channels (KATP) [1].
Highlights
Mitochondrial dysfunction and consequent cellular energetic failure play a key role in the development of sepsis-related organs failure
Levosimendan group had a greater decrease in L/P ratio and a greater increase in MD pyruvate at the 72 th 72th hour compared with the placebo group (p = 0.043)
From 48th to 72th hours, Tissue L/P clearance was significantly higher in levosimendan-treated patients compared with placebo (H48 (p = 0.015), H54 (p = 0.032), H60 (p = 0.016) et à H72 (p = 0.007))
Summary
The aim of the present study was to evaluate the effects of levosimendan on muscle metabolism compared with placebo and dobutamine in patients with spetic shock
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