Abstract
BackgroundThe ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats. This study was to explore the effects and differences of KD with or without medium-chain fatty acids (MCFAs) on serum inflammatory factors and mTOR pathway in Sprague–Dawley (SD) rats.ResultsMale SD rats were assigned to five groups: control diet (C), 20% caloric restriction diet (LC), 20% caloric restriction ketogenic diet (containing MCFAs) (LCKD1), 20% caloric restriction ketogenic diet (LCKD2) and 20% caloric restriction foreign ketogenic diet (LCKD3), and fed for 30 d. LC and KD could significantly reduce the body weight of rats; LC and KD containing MCFAs showed anti-inflammatory effects; KD without MCFAs decreased the concentration of mTOR1, while KD containing MCFAs decreased the expression of AMPK, mtor1 and P70sk.ConclusionsKD containing MCFAs showed better effects on the mTOR pathway and anti-inflammation than that without MCFAs.
Highlights
The ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats
The aim of the present study was to explore the effects of KD on serum hormones, ketone bodies, blood sugar, inflammatory factors and mTOR signaling pathways in rat fed with ketogenic diet containing medium-chain fatty acids (MCFAs)
The results showed that 20% Caloric restriction ketogenic diet (LCKD1) and 20% Caloric restriction ketogenic diet (LCKD2) groups reduced the mTOR1 level when compared with 20% Caloric restriction diet (LC) group
Summary
The ketogenic diet (KD) can promote the anti-inflammatory metabolic state and increase ketone body level in rats. This study was to explore the effects and differences of KD with or without medium-chain fatty acids (MCFAs) on serum inflammatory factors and mTOR pathway in Sprague–Dawley (SD) rats. Ketogenic diet (KD) is a special diet formula that consists of high fat, appropriate protein, low carbohydrate and appropriate other nutritional elements [1,2,3]. It can improve the incidence of epilepsy. It uses fat instead of glucose as the energy source to increase the efficiency of ketone production and protects nerves from damage. KD has once again attracted much attention due to its
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