Effects of Jinshuibao capsule combined with compound α-ketoacid tablets on renal impairment caused by anti-tuberculosis drugs

Abstract

Objective To observe the clinical efficacy of Jinshuibao capsule combined with compound α-ketoacid tablets on renal impairment caused by anti-tuberculosis drugs. Methods Seventy-two pulmonary tuberculosis patients with renal impairment caused by anti-tuberculosis drugs who were treated in Henan Infectious Disease Hospital from April 2017 to April 2018 were selected, and they were divided into treatment group and control group according to random number table method, with 36 cases in each group. Patients in treatment group were treated with Jinshuibao capsule combined with compound α-ketoacid tablets and conventional treatment, and patients in control group were treated with compound α-ketoacid tablets and conventional treatment, with 14 days as a course. The clinical efficacy, the levels of creatinine and urine protein of two groups were detected before and after treatment. Results The clinical symptoms of the two groups were improved than before, the total efficiency of treatment group was 97.3%, which was higher than control group (83.7%), the difference was significant (P<0.05). After treatment, levels of creatinine and urinary protein in the two groups were lower than those before treatment, and treatment group had lower level of the two indexes than control group (P<0.05). Conclusions Jinshuibao capsule combined with compound α-ketoacid tablets can effectively treat the renal impairment caused by anti-tuberculosis drugs, of which the curative effect is definite, so it is worthy of clinical application. Key words: Jinshuibao capsule; Anti-tuberculosis drugs; Renal impairment; Clinical curative effect