Abstract
We investigated the hypothesis that cerebral prostanoid and peptidoleukotriene (LTs) (LTC 4/D 4/E 4/F 4) synthesis are increased during postischemic reperfusion of newborn pig brains. Prostanoids and LTs extracted from brain tissue were determined by RIA in sham-control piglets and at, 1h, 3h, or 12h after a 20-min period of total cerebral ischemia. During reperfusion following ischemia, all regional brain tissue (cerebrum, brain stem and cerebellum) prostanoids (6- keto-PGF 1α, TXB 2, PGE 2 and PGF 2 α ) were increased at 1h compared with those in sham-control piglets. Only cerebral and brain stem 6- keto-PGF 1 α and cerebral TXB 2 remained elevated at 3h postischemia and all prostanoids returned to control levels by 12h postischemia. Brain tissue LTs were lower than prostanoids and were not altered 1, 3, or 12h following ischemia. These data indicate that 1) newborn pig brain tissue prostanoids are increased initially, and then returned to control levels at later stages of reperfusion followign ischemia; 2) LTs are present in newborn pig brain tissue, but are not increased by ischemia/reperfusion injury and therefore probably do not play a significant role in cerebral ischemia-reperfusion injury.
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