Abstract
Rats injected through permanent intraventricular cannulas with 8 μg of norepinephrine, 32 μg of dopamine or 8 μg of serotonin were tested 5 min later by the measurement of the electroshock seizure threshold and the duration of various components of tonic-clonic seizures induced electrically or with flurothyl. Each of the monoamines decreased the threshold for the minimal seizure and increased the duration of the tonic extension and postictal depression phases of maximal electroshock convulsions. The findings with flurothyl were less consistent among the monoamines, but decreased latencies for the myoclonic jerk and generalized convulsions and prolonged recovery from the seizure were observed. With the doses used all the monoamines produced hypothermia. In animals supplied with sufficient external heat to prevent hypothermia, the decreased electroshock seizure threshold was returned to normal. These findings indicate that the seizure-facilitating effects of intraventricularly administered monoamines are attributable to decreased body temperature.
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