Abstract
Objective To investigate the effects of intraventricular microinjection of L-dopa on behaviors and the number of dopaminergie neurons in rat Parkinson disease(PD)models.Methods The rat models of hemiparkinsonism were established with 6-hydroxydopamine(6-OHDA),stainless steel guide cannulas(0.7 mm)was implanted,and L-dopa with different concentrations was microinjected into the intracerebrai ventricle of the rats.One week later,changes in behaviors and the number of dopaminergic neurons in substantia nigra were monitored at different time points.Results Microinjeection of 1 g/L L-dopa could significantly decrease the rotations induced by APO in rat PD models(P ＜ 0.01),and the effect achieved summit in 2 h.The number of dopaminergic neurons in substantia nigra wasalso increased markedly(P ＜ 0.01).Conclusion Intraventricular microinjection of L-dopa can relieve the rotation behaviors and increase the number of dopaminergic neurons in rat PD models. Key words: Parkinsonian rat model; Intraventricular injection; L-Dopa
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