Abstract
The effects of cholecystokinin-8 ( cck-8) and pentagastrin on insulin and glucagon secretion were studied in conscious sheep. Intravenous infusions of ccx-8 (3 to 1000 pmol kg −1 min −1 for 30 minutes) induced a dose-dependent increase in plasma insulin, but did not alter plasma glucagon concentration. The threshold dose of ccx-8 for stimulation of insulin secretion was 10 to 30 pmol kg −1 min −1. Pentagastrin was infused intravenously at doses of 10 to 3000 pmol kg −1 min −1. The maximal dose of pentagastrin slightly stimulated insulin, but not glucagon, secretion. The insulin secretory activity of pentagastrin was only 1/300 that of ccx-8 on a molar basis. The threshold dose of ccx-8 for stimulation of insulin secretion was similar to that for exocrine pancreatic secretion obtained in earlier studies. In conclusion, ccx is a potential candidate as a physiological factor regulating insulin secretion in sheep.
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