Abstract
It is widely believed that the neural patterns of temporal coding within the auditory periphery and CNS change following cochlear hearing loss, and a number of recent studies have aimed to more fully understand and characterize these changes. In these studies, noise exposure has been a common method for inducing hearing loss in animal models. Unfortunately, its effects are nonspecific, affecting both inner and outer hair cells as well as the surrounding tissues. Because of this mixed hair-cell damage, it has been difficult to tease apart the specific effects that each of these pathologies has on temporal coding. In the present study, we used the chemotherapy drug carboplatin to induce inner hair cell (IHC) specific lesions in the cochleae of chinchillas. Using acoustically evoked potentials and acute single fiber recordings from the auditory nerve, in parallel with computational modeling, we have investigated the effects of IHC damage on temporal coding. Preliminary findings in carboplatin exposed chinchillas, which show near-normal ABR thresholds, showed a decrease in ABR amplitudes at high sound levels, as well as a decrease in the strength of both envelope and fine-structure coding in frequency following responses. [Research supported by NIH (NIDCD) R01-DC009838 and T32-DC00030.]
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