Abstract
Interferon may be induced in cervical carcinoma <i>in situ</i> by inoculation of either live virus measles vaccine or the synthetic polynucleotide, Poly I: C. Changes were observed in tumor cells with no changes in normal cells and tissues. Tumor cell changes were characterized by ‘punched-out’ holes in nuclei, vacuoles in the cytoplasm and elimination of nuclear DNA in altered cells. A high local concentration of Poly I: C in the region of the localized <i>in situ</i> lesions, it is believed, leads to interferon production by cells in or adjacent to the cancer producing antiviral influence presumably affecting viral components in tumor cells. In previous studies of antitumor effects of Poly I: C in advanced human malignancies, it was concluded by other investigators that the dosage was too low to affect recognizable changes in tumors. Poly I: C is regarded as a significant experiment directly upon tumor cells revealing effects of interferon upon human cells of this early cancer type.
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