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Abstract
Effects of iguratimod on protein profiles of chondrosarcoma cells
Highlights
Rheumatoid arthritis (RA) is a systemic inflammatory disease that causes progressive joint destruction and functional loss [1]
We determined the concentration of IGU as 100 μM and analyzed protein profile of OUMS-27 cells at this condition
It was shown that IGU affected the protein profile of OUMS-27 cells
Summary
Rheumatoid arthritis (RA) is a systemic inflammatory disease that causes progressive joint destruction and functional loss [1]. Developments of biologics and small-molecule immunosuppressive disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate and janus kinase inhibitors have enabled this strategy [1, 2]. For RA patients that achieved the remission, application of treatments with immunomodulatory drugs should be considered. From these points of view, the role of conventional diseasemodifying anti-rheumatic drugs (cDMARDs) is important in RA treatment. IGU has been considered to exhibit its anti-rheumatic effects through suppression of NF-κB, by the inhibition of phosphorylation and nuclear translocation of RelA/ p65 without interfering with IκB [6, 7, 9]. Mechanisms of the effects of IGU, especially those on chondrocytes, are still obscured
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