Effects of Hypoxic Training on Serum Lipoprotein of Obese Rats

Abstract

ObjectiveTo study the effects of hypoxic training on serum lipoprotein of obese rats.Method130 obese rats were divided into 13 groups at random:control group, normoxic training 1,2,3,4 week group, hypoxia sedentary1,2,3,4 week group, and hypoxic training 1,2,3,4 week group. The rats in training groups ran on a treadmill for 60 min a day at 26 m/min in normoxia or 21 m/min in hypoxia(13.6%), 6 days a week for 1–4 weeks. After corresponding week, the serum level of cholesterol(TC), triglyceride(TG), high‐density lipoprotein(HDL), low‐density lipoprotein (LDL), apolipoprotein AI (ApoAI) and apolipoprotein B(ApoB) were measured.Results1) hypoxic training significantly reduced serum TC, TG and ApoB of obese rats respectively in 1–4week,3–4week and 1–2week, and serum TC, TG and ApoB were also lower in above hypoxic training groups compared with the corresponding week groups of normoxic training and hypoxia sedentary. 2) hypoxic training significantly increased serum HDL and ApoAI of obese rats respectively in 3–4week and 1–4week, and serum HDL and ApoAI were also higher in above hypoxic training groups compared with the corresponding week groups of normoxic training and hypoxia sedentary.ConclusionHypoxic training can ameliorate serum lipoprotein in obese rats especially in 3–4 week, the effect is also better than hypoxia sedentary and normoxic training.(Supported by NSFC: Grant No. 30971415)