Effects of hypothermia therapy on coagulopathy in neonates with hypoxic-ischemic encephalopathy of diffe-rent degrees

Abstract

Objective To study the effects of hypothermia therapy on coagulopathy in neonates with hypoxic-ischemic encephalopathy(HIE) of different degrees. Methods Twenty-five newborns with HIE were divided into 2 groups (moderate HIE group and severe HIE group) by amplitude integrated electroencephalogram(aEEG). The platelet (PLT) count, activated partial thromboplastin time (APTT), prothrombin time(PT), thrombin time(TT), fibrinogen (Fbg) and international normalized ratio (INR) were measured before hypothermia therapy and those after 24 hours, 48 hours, 72 hours after hypothermia therapy were collected.The hematological parameters of 2 groups were analyzed by repeated measurement analysis of variance. Results The APTT(t=2.239, P 0.05)showed no statistically significant difference between 2 groups after hypothermia therapy.The differences in INR(F=12.470, P 0.05) between 2 groups.The differences in PLT(F=32.420, P 0.05). But the degree of brain injury and time had interactive effects in PT(F=3.374, P 0.05). Conclusion The coagulopathy function is worse in neonates with severe HIE in hypothermia therapy which may aggravate the hemorrhage risk.And the effect of hypothermia on neonates with moderate HIE is less evident.So hierarchical intervention on coagulopathy in neonates with HIE during hypothermia should be adopted to relieve the hemorrhage risk. Key words: Hypothermia; Hypoxic-ischemic encephalopathy; Coagulopathy; Amplitude integrated electroencephalogram