Abstract
Cardiac output during exercise is decreased after a prolonged sojourn at high altitude. The maximal oxygen uptake at high altitude, which persists at a low value even after arterial oxygen content normalizes, is reduced because of these changes in cardiac output. Alterations of both heart rate and stroke volume contribute to this decrease. The etiologies of these changes are not known, but failure to restitute stroke work to sea-level values with dextran 75 infusion suggests altered myocardial function. The superior physical performance of high-altitude natives may be due to cardiovascular adaptation to hypoxia.
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