Abstract

The present study was undertaken to investigate the effects of ganoderma lucidum spores (GLS) on expression of polysialic acid neural cell adhesion molecule (PSA‐NCAM) and hippocampus mossy fiber sprouting (MFS) in pentylenetetrazol (PTZ)‐induced epileptic rat model. Thirty male Sprague‐Dawley rats (180–220g) were divided into three groups: control, GLS and epilepsy model groups. The results showed that, compared with epilepsy model groups, the rats of GLS group have longer latent periods, and lower seizure level. Their seizure durations also were shorter than epilepsy model group. In the granular cell layer of dentate gyrus and stratum pyramidal and stratum oriens of the CA3 region, epilepsy model group have more PSA‐NCAM than GLS group and control group; compared with epilepsy model group, MFS in the granular cell layer of dentate gyrus were obviously less in GLS group, and no statistically significant difference was detected when compared with control group; in the stratum pyramidal and stratum oriens of the CA3 region, MFS in GLS group was less than epilepsy model group, but obviously more than control group.ConclusionFor PTZ induced epileptic rats, there were different severities of MFS in different regions of hippocampus. GLS can decrease expression of PSA‐NCAM and MFS effectively, and that might be one of its mechanism of lighten rats′ seizure induced by PTZ.

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.