Abstract
Pancreatic adenocarcinoma is one of the lethal types of cancer worldwide. This study aimed to evaluate the cytotoxic effects of FOLFIRINOX compounds [oxaliplatin (OXA), irinotecan (IRI), fluorouracil (5FU), and leucovorin (LEU)] on a pancreatic adenocarcinoma cell line (PANC-1), both individually and collectively. Cell viability was determined using the colorimetric MTT reagent and apoptosis was assessed using the propidium iodide – Hoechst 33342 staining assay. Based on cell viability data, 5FU and FOLFIRINOX treatments were more potent against PANC-1 than the other test groups. The apoptotic trend, nevertheless, was not different between them and the control group. Moreover, OXA, LEU, and IRI significantly increase apoptotic cell death. Our findings indicate that 5FU and FOLFIRINOX are comparably effective in reducing the PANC-1 cell viability. In the future, 5FU and FOLFIRINOX may be adapted to local pancreatic adenocarcinoma treatments, but the development of these localized drug release platforms requires further attention as the microenvironment of pancreatic adenocarcinoma inherently contains many unknowns.
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