Abstract
The circular smooth muscles of the middle colon of the rabbit generate giant contractions of high amplitude and low frequency. Flavone, at various concentrations, reduces the giant contractions and the tonic contraction induced by 10µM carbachol and 80mM KCl. The contractions induced by dequalinium and tetraethylammonium are reduced by flavone (30µM). At 100µM, flavone decreases the contraction induced by 100µM methylene blue and 1mM orthovanadate. These results suggest that flavone inhibit the giant contractions by (1) inhibition of voltage-dependent Ca2+ channels, (2) activation of guanyl cyclase, (3) opening of K+ channels and (4) inhibition of tyrosines kinases.
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