Abstract
BackgroundThe high morbidity of metabolic dysfunction diseases has heightened interest in seeking natural and safe compounds to maintain optimal health. γ-Oryzanol (OZ), the ferulic acid (FA) ester with phytosterols, mainly present in rice bran has been shown to improve markers of metabolic syndrome. This study investigates the effects of FA and OZ on alleviating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome parameters.MethodsMale SD rats were fed with a regular rodent diet, HFFD, or HFFD supplemented with 0.05% FA or 0.16% OZ (equimolar concentrations) for 13 weeks. Food intake, organ indices, serum lipid profiles, glucose metabolism, insulin resistance (IR) index and cytokine levels were analyzed. The mechanisms were further investigated in oleic acid-stimulated HepG2 cells by analyzing triglyceride (TG) content and lipogenesis-related gene expressions.ResultsIn the in vivo study, FA and OZ exhibited similar effects in alleviating HFFD-induced obesity, hyperlipidemia, hyperglycemia, and IR. However, only OZ treatment significantly decreased liver index and hepatic TG content, lowered serum levels of C-reactive protein and IL-6, and increased serum concentration of adiponectin. In the in vitro assay, only OZ administration significantly inhibited intracellular TG accumulation and down-regulated expression of stearoyl coenzyme-A desaturase-1, which might facilitate OZ to enhance its hepatoprotective effect.ConclusionOZ is more effective than FA in inhibiting hepatic fat accumulation and inflammation. Thus, FA and OZ could be used as dietary supplements to alleviate the deleterious effects of HFFD.
Highlights
Metabolic syndrome (MS) is a cluster of metabolic dysfunctions that includes hyperglycemia, hypercholesterolemia, hypertriglyceridemia and insulin resistance (IR), and accompanies type 2 diabetes mellitus, obesity and cardiovascular diseases. [1,2]
This study investigates the effects of ferulic acid (FA) and OZ on alleviating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome parameters
OZ is more effective than FA in inhibiting hepatic fat accumulation and inflammation
Summary
Metabolic syndrome (MS) is a cluster of metabolic dysfunctions that includes hyperglycemia, hypercholesterolemia, hypertriglyceridemia and insulin resistance (IR), and accompanies type 2 diabetes mellitus, obesity and cardiovascular diseases. [1,2]. The high morbidity of MS can be partly attributed to modern dietary patterns. Dietary fructose is almost totally absorbed and metabolized rapidly by the liver, undergoing a markedly different metabolic fate from glucose metabolism, resulting in deleterious effects, such as IR, obesity and hyperuricemia [7]. We have previously shown that fructose worsens the adverse effects of dietary fats on serum glucose and lipids regulation [8]. There is a heightened interest in identifying highly effective compounds that lessen the healththreatening effects of fructose and fats while maintaining food palatability. The high morbidity of metabolic dysfunction diseases has heightened interest in seeking natural and safe compounds to maintain optimal health. This study investigates the effects of FA and OZ on alleviating high-fat and high-fructose diet (HFFD)-induced metabolic syndrome parameters
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
