Abstract
In the first experiment, dose-inhibition and time functions are documented for the anorectic effects of d, l-fenfluramine in Syrian hamsters ( Mesocricetus auratus). A dose of 20 mg/kg (IP) inhibited feeding for at least 2–4 hr. In the second experiment, chronic treatment of hamsters housed either in running wheels (exercise) or standard (sedentary) conditions with d, l-fenfluramine (20 mg/kg) produced an attenuation of weight gain relative to vehicle-treated controls. However, there was no differential weight loss in the exercising drug-treated group. This result was also obtained using 10 mg/kg d-fenfluramine. In the third experiment, d, l-fenfluramine greatly inhibited gastric emptying of a test meal in hamsters. In the fourth experiment, hamsters were found to sustain only small and transient decreases in brain 5HT and 5HIAA levels after acute or chronic treatment with d, l-fenfluramine. These findings are compared and contrasted with the known effects of fenfluramine in rats. It is concluded that there may be species differences in the impact of fenfluramine on brain function and that this may not be in any simple way related to the anorexigenic action of this drug.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
