Abstract
Abstract The feeding of penicillin to broilers and laying hens did not result in the deposition of any penicillin activity in the blood, muscle, liver, kidneys, or eggs. About 9 8% of the penicillin activity was destroyed in the upper portion of the intestinal tract with very little activity reaching the small intestine. When penicilloic acid, one of the degradation products, was fed to broilers it stimulated the development of lactosefermenting organisms in the intestinal tract, which showed antibiotic resistance as reflected by the streptomycin and tetracycline resistance markers.
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