Abstract
T H E association of malnutrition with endocrine dysfunction has long been recognized, but investigation of the effects of specific deficiencies has been possible only during the past 40 years. Progress has been rather slow, but it has become apparent that the immature animal is particularly susceptible and that disturbance of the pituitary-gonad axis is usually the most sensitive index of nutritional deficiency. The pituitary-thyroid and pituitary-adrenocortieal axes may become involved with increasing severity of the deficiency (e.g., pseudohypophysectomy of malnutrition 1 or anorexia nervosa 2) and it is generally true that the pituitary gland is more often primarily affected, although direct effect on end organs also occurs. The catalogue of reports relating to experimental deficiency in both animals and man is exten-
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