Abstract
Summary 1.Extracts were made of 13 islet cell tumors by means of a technique described by Gregory and his associates. 2.Extracts of islet cell tumors from 2 patients who had hyperinsulinism contained a substance presumed to be insulin that produced both hypoglycemia and gastric secretion in dogs with vagally innervated pouches. One of these was tested in a dog with a vagally denervated pouch and was inactive. 3.An extract of a nonfunctioning islet cell tumor of the pancreas produced neither hypoglycemia nor gastric secretion. 4.Extracts were made of five primary and five metastatic islet cell tumors from patients who had the Zollinger-Ellison syndrome. A gastric secretagogue was demonstrated in nine of the extracts but was not detected in one of the metastatic tumors. Extracts of two primary tumors produced hypoglycemia in dogs despite the fact that hypoglycemia had not been present clinically. In other cases, a gastric secretagogue was demonstrated that was not insulin, adding to the mounting evidence that islet cell tumors in patients with the ZollingerEllison syndrome produce a stimulant for gastric secretion.
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