Abstract
The cardiovascular and renal actions of dopamine (DA) involve the activation of α- and β-adrenoceptors as well as specific DA receptors [1–3]. These peripheral DA receptors are now subdivided in two distinct subtypes, namely DA-1 and DA-2 receptors. The anatomical location of these DA receptors as well as the pharmacological responses elicited during their activation is shown in Table 1, which also provides some specific examples of selective agonists that act at these two different DA receptor subtypes. It is evident that activation of these receptors will lead to pronounced changes in the cardiovascular and renal function and more importantly the changes produced by these agents will be of therapeutic benefit in acute and chronic treatment of cardiovascular and renal diseases. This chapter deals mainly with the cardiovascular and renal actions of some of these compounds that are mediated via activation of DA-1 receptors and discusses their therapeutic implications as it relates to intensive care and emergency medicine.
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