Effects of corn oil as a vehicle- on liver of female Swiss albino mice Mus musculus

Abstract

The study was conducted to evaluate corn oil as a vehicle for delivery of toxins and to observe its effect on liver of female Swiss albino mice. Mice were randomly divided into five groups of six mice each and were administered corn oil at a dose of 10 ml /kg body weight orally for a period of six weeks. Mice of control Gr-1 were kept on normal diet and tap water ad libitum. Histopathological examination of the liver of female albino mice revealed mild alteration in Gr.-4 and mild fatty degeneration was observed in Gr.-5. Mice in Gr.-2 and Gr.-3 showed neither abnormal conditions nor any change in the liver architecture. The biochemical parameters like SGPT, ALP, total protein, and albumin (LFT) were estimated for all the treatment groups and compared with their normal values of the contnDl Gr.-1. Statistical analysis was done using one way analysis of variance (ANOVA). The values obtained were not significant (P>0.05) in all the treated groups for all the biochemical parameters. However the levels of ALP and Albumin in Gr.-5 were higher as compared to the control Gr-1. These data indicate that corn oil at the dose of 10 ml/kg body weight can be used as a vehicle for toxicological studies but may cause adverse effects on the hepatic tissue if used for prolonged periods, suggesting that corn oil as a vehicle can be a confounding factor in the toxicity study depending on time and dose