Abstract
The experiments described herein were performed on isolated, spontaneously beating rabbit atria. The muscarinic actions of acetylcholine in the presence of physostigmine were antagonized by pyrilamine, chlorpheniramine and procaine which demonstrates that these drugs have an “antimuscarinic” action. The nicotinic (positive inotropic and chronotropic) actions of acetylcholine in the presence of atropine were also antagonized by pyrilamine and chlorpheniramine. Cocaine, pyrilamine, and chlorpheniramine inhibited the atrial stimulation by tyramine and ephedrine. The fact that the antimuscarinic and antinicotinic effects of pyrilamine and chlorpheniramine show similar slopes may indicate that similar receptors are involved. Cocaine and pyrilamine also have parallel slopes indicating that pyrilamine has a cocaine-like effect which is not related to local anesthesia.
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