Abstract
Cannabidiol supplements (CBD) are increasingly consumed by athletes to improve regeneration. However, the evidence for the pro-regenerative effects of CBD in sports is quite limited. Therefore, our aim was to investigate the effects of a single CBD supplementation in a six-arm placebo-controlled crossover study after resistance training on performance and muscle damage. Before and after the resistance training, one-repetition maximum in the back squat (1RM BS), countermovement jump (CMJ), and blood serum concentrations of creatine kinase (CK) and myoglobin (Myo) were measured in healthy, well-trained participants. 16 out of 21 participants completed the study and were included in the analysis. In 1RM BS, a significant decrease was observed after 24 h (p < 0.01) but not after 48 and 72 h. A significant group difference was detected after 72 h (p < 0.05; ES = 0.371). In CMJ, no significant changes were observed. The CK and Myo concentrations increased significantly after 24 h (CK: p < 0.001; Myo: p < 0.01), 48 h (CK: p < 0.001; Myo: p < 0.01) and 72 h (CK: p < 0.001; Myo: p < 0.001). After 72 h, significant group differences were observed for both muscle damage biomarkers (CK: p < 0.05 ES = 0.24; Myo: p < 0.05; ES = 0.21). The results show small but significant effects on muscle damage and recovery of squat performance after 72 h. However, more data are required for clearer statements concerning potential pro-regenerative effects of CBD supplementation after resistance training.
Highlights
Intense training and performance result in damage and inflammation of the skeletal muscles [1,2,3]
This study examined the effect of a single CBD supplementation following an intensive strength protocol on skeletal muscle damage and lower body performance
The results clearly show an increase in creatine kinase (CK) and Myo concentration in both groups at all time points (T 24, T 48, T 72) with significant differences between the groups at T 72 (ES: CK = −0.236; Myo = −0.214)
Summary
Intense training and performance result in damage and inflammation of the skeletal muscles [1,2,3]. CBD is used in a variety of diseases such as autoimmune encephalitis [19], rheumatoid arthritis [20], colitis [21], diabetes [22], and psoriasis [23], as well as Alzheimer’s [24], Parkinson’s [25], and Huntington’s Disease [26]. It has anticonvulsant [14,27,28,29], antipsychotic [14,27,30], antiemetic [14,27], anticarcinogenic [31,32], and antidepressant [14,33] effects. Regulations regarding its legality vary among countries worldwide [34,35], CBD was removed from the World
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