Effects Of Candesartan Cilexetil Drug And Allium Sativum On Certain Enzymes And Biochemical Parameters In Hyperlipidemic Mice

Abstract

The present study was performed to investigate the possible correlation between the effects of candesartan cilexetil (3 mg/kg b.w.) and garlic; allium sativum (100 mg/kg b.w.) alone and in combination on high cholesterol diet (HCD) male mice . Candesartan cilexetil alone and their combination with garlic were given orally to animals fed on hypercholesterolemic diet by gavage for 12 weeks . Results of this investigation showed that animals under high cholesterol diet exhibited some sort of changes in the blood, plasma and tissue levels of leukocytes,cholesterol, triglyceride and enzymes where they increased significantly while some decrease exhibited in heart weight, LDH-cholesterol and testosterone hormone compared with that of the normal diet animals. Candesartan cilexetil garlic or their combination significantly decreased the plasma and tissue levels of total cholesterol (TC), triglyceride (TG) , while they increased significantly the levels of high density lipoprotein cholesterol ( HDL-C). On the contrary, candesartan and candesartan in combination with garlic decrease WBCs, neutrophils and platelets significantly in compared with that of the (HCD) animals. This study included the total body and heart weights. Heart weight increased significantly in candesartan, garlic and their combination treated group. On the other hand, there were significantly decreases in body weight in candesartan, garlic and their combination compared with that of the high cholesterol diet treated animals. The effect of candesartan, garlic and their combination upon serum and liver levels of ALP, AST, ALT and ChE enzymes were investigated. Serum and liver ALP, AST, ALT and ChE were increased significantly in candesartan treated group but they decreased markedly in garlic and its combination with candesartan in serum and liver respectively compared with that of the high cholesterol diet animals. Candesartan decreased plasma level of testosterone while garlic and its combination with candesartan increased the testosterone hormone significantly compared with that of the high cholesterol diet animals. In conclusion, animals given garlic have improved physiological functions and induced significant causes of antiatherosclerosis effect. Also, these observations show that garlic is efficacious in lowering blood lipid profils and thereby could maintain protection with hypertensive drugs.